Irritant Volatile Anesthetics Induce Neurogenic Inflammation Through TRPA1 and TRPV1 Channels in the Isolated Mouse Trachea

Abstract

Our results confirm the clinical experience that desflurane is more irritating than isoflurane at equal anesthetic gas concentration, whereas sevoflurane does not activate tracheobronchial sensory nerves to release neuropeptides and induce neurogenic inflammation. Both irritant receptor channels, TRPA1 more than TRPV1, are involved in mediating the adverse effects that may even extend to systemic proinflammatory sequelae.