Publication | Closed Access
Practical and Cost-Effective Manufacturing Route for the Synthesis of a β-Lactamase Inhibitor
50
Citations
8
References
2013
Year
Cost-effective Manufacturing RoutePolycyclic MoleculeEngineeringAntimicrobial ChemotherapyPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryAntimicrobial Therapyβ-Lactamase InhibitorCompound 1Antimicrobial ResistanceAntimicrobial Drug DiscoveryAntibacterial AgentAntimicrobial PharmacokineticsAntimicrobial CompoundDrug DevelopmentPharmacologyBiomolecular Engineeringβ-Lactam AntibioticsAntibioticsBiotechnologyMicrobiologyAntimicrobial AgentsAntimicrobial PharmacodynamicsMedicineDrug Discovery
Compound 1, a potent and irreversible inhibitor of β-lactamases, is in clinical trials with β-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.
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