Human In Vivo Comparative Study of Zinc and Copper Transmetallation After Administration of Magnetic Resonance Imaging Contrast Agents

Abstract

The difference in observed zinc excretion among the chelates studied reflects in vivo transmetallation of the magnetic resonance contrast media and correlates with the respective kinetic inertia for transmetallation, rather than thermodynamic stability constants. Gadolinium-HP-DO3A was found to be the most kinetically inert among the three drugs tested.