Immune reconstitution in HIV-1-infected children on antiretroviral therapy: role of thymic output and viral fitness

Abstract

These findings indicate that recovery of thymic function is a pivotal event in immune reconstitution, and suggest that CD4 T-cell increase despite persistent viraemia is sustained by a continuous thymic output that compensates peripheral CD4 T-cell depletion which might be slowed down by emerging viruses with reduced fitness.