Chiral 1,4‐bensodiazepines. V. ‐ synthesis and properties of 1,4‐benzodiazepin‐2‐ones containing α‐amino acids as a part of the 1,4‐diazepine ring

Abstract

Abstract Chiral 1,4‐benzodiazepin‐2‐ones XIII‐XXIIII (Scheme 1) were prepared starting from N ‐protected α‐amino acids and 2‐amino‐5chlorobenzeophenone; the intermediates I‐XII were isolated and identified. Spectroscopie propertiec of these componds are discussed (ir, nmr); their optical stability, as well as the cyclization rate for XII‐XIII in buffer solution have been determined.