Journal of Economic Entomology · 1967 · 13 citations · 0 references
Veterinary MedicineEntomologyToxicologyComparative ToxicologyInsect ToxicologyPesticide ToxicologyInsecticide ResistanceInsecticide ToxicityInsecticide ToxicologyMechanisms Of Pesticide ToxicityPesticide ChemistryPesticide Impacts On InsectsInsect Mortality BioassaysPesticide Exposure EffectsPublic Health EntomologyPyrethroid ResistanceSublethal Insecticide ExposureToxicodynamics Of InsecticidesToxicokinetics Of Insecticides
Comparative toxicity tests with DDT and o-Cl-substituted DDT-derivatives showed that o-Cl-DDT was the most toxic compound to DDT-resistant house flies, Musca domestica L. Steric hindrance caused by the a-chlorine atom reduces the enzymatic dehydrochlorination of the and, correspondingly, restores its toxicity against the resistant strains. One strain, highly resistant to o-Cl-DDT, did not dehydrochlorinate the latter compound to a great extent, but the resistance mechanism is not known. Deuterated-DDT is only slightly more toxic than DDT to DDT-resistant house flies. At low dosages the latter can dehydrochlorinate dentero-DDT with equal facility as ordinary DDT, hut at higher dosages an isotope effect on dehydrochlorination is evident.