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The Synthesis of Ribosomal RNA in Different Organisms: Structure and Evolution of the rRNA Precursor
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1970
Year
Ribosomal RnaGeneticsMolecular BiologyMolecular GeneticsGene TranscriptionProtein SynthesisBiosynthesisBiological SynthesisGene StructureRrna PrecursorRna Structure PredictionRna BiologyDna ReplicationRna TransportDirect ProductGene ExpressionStructural BiologyBiologyChromatinNatural SciencesDifferent OrganismsCorresponding Chromosomal RegionMicrobiologyMedicine
The synthesis of ribosomal RNA (rRNA) provides at present the only system in higher organisms in which the activity of a gene and its product can be studied directly. It is the only case in which a gene of known function can be isolated (Birnstiel et al., 1966), the behavior of the corresponding chromosomal region can be studied cytologically (McClintock, 1934), and the direct product of transcription and its maturation and transport into the cytoplasm can be followed in great detail (Perry, 1967; Weinberg, Loening, Willems, and Penman, 1967; Darnell, 1968; Maden, 1970).