Relationships between crystallinity of .BETA.-cyclodextrin and tablet characteristics.

Abstract

The effects of the crystallinity of β-cyclodextrin (β-CD) on the hardness, apparent density and disintegration time of β-CD tablet have been studied. β-CD powders with various degrees of crystallinity were prepared by grinding and used for tableting. The crystallinity was measured by the X-ray diffraction method. Linear relationships were found between tablet compression force and tablet hardness. It was also observed that decreasing crystallinity caused an increase of tablet hardness as well as disintegration time. The results indicate that crystallinity is one of the important factors controlling tablet characteristics.