A Comparison of Erythropoietin Bioassays

Abstract

The transfused plethoric mouse is sensitive to quantities of erythropoietin as small as 0.05 unit as measured by radioiron administered 2 1/2 days after challenge with the hormone. A sigmoidal curve describes the relationship between incremental log-doses of purified erythropoietin and incorporation of radioiron into circulating red blood cells.