Development of Neurologic Manifestations of Pernicious Anemia during Multivitamin Therapy

Abstract

IN SOME patients with pernicious anemia neurologic manifestations occur before significant anemia develops. Such cases have been uncommon in the past. At the Johns Hopkins Hospital in the five-year period prior to 1950, the diagnosis of pernicious anemia was established in 58 patients in whom the disease had not previously been recognized. In 8 of these patients blood values were essentially normal at the time the diagnosis was made. However, in 7 of these 8 cases anemia was known to have been present prior to admission, and there was a definite history of treatment with folic acid, liver extracts or . . .