Concepedia

Somatostatin Inhibition of Glucagon-Stimulated Adenosine 3'-5'-Monophosphate Accumulation in Isolated Hepatocytes

J. R. Oliver, Kathryn J. Long, S.R. Wagle, Donald O. Allen

Experimental Biology and Medicine · 1976 · 22 citations · 0 references

Concepts

Life SciencesBiochemistryEndocrinologyCell SignalingSignal TransductionCyclic Nucleotide SignalingHormone SecretionAdenylyl Cyclase RegulationCyclic Adenosine Monophosphate PathwayCyclic Adenosine Monophosphate SignalingCyclic FormHepatocyte Glucagon SignalingSomatostatin PharmacologySomatostatin SignalingSomatostatin-mediated Inhibition

Abstract

The cyclic form of somatotropin release inhibitor factor over a concentration range from 0.50 to 8.0 μg/ml was found to inhibit glucagon-stimulated cyclic AMP accumulation in isolated rat hepato-cytes.