Regulation of T-Lymphocyte CCL3 and CCL4 Production by Retinal Pigment Epithelial Cells

Abstract

RPE cells are able to down-regulate high levels of CCL3 and CCL4 production by T lymphocytes by using the soluble mediators sCD54 and PGE2. Reducing this production of CCL3 and CCL4 will dampen down the cascade effect and recruitment of more inflammatory cells, protecting the retina from an excessive immune response.