American Journal of Clinical Pathology · 1972 · 17 citations · 0 references
MedicineHematologyPharmacologyHemostasisTherapeutic Drug MonitoringTransfusion MedicineAnticoagulant ManagementAnticoagulant TherapyAnticoagulation ManagementAnticoagulation TherapyAntithrombotic Drug MonitoringHeparin AnticoagulationHeparin-mediated AnticoagulationMonitoring Of Anticoagulant TherapyNeutralizationPlasma SamplingProtamine Administration
Grann, Victor R., Homewood, Kathryn, and Golden, Walter: Polybrene neutralization as a rapid means of monitoring blood heparin levels. Am. J. Clin. Pathol. 58: 26–32, 1972. Polybrene neutralization is a rapid and accurate test for determining and following heparin anticoagulation. The method and five studies are described. In addition to its simplicity, this test offers the added advantage of following heparin therapy at high concentrations in the blood and in patients receiving Warfarin anticoagulants. It also permits quantification of dosage of protamine when neutralization with heparin is necessary.