Organic Letters · 2014 · 200 citations · 36 references
Phenylacetic AcidsPhenylacetic Acid FrameworkEngineeringCross-coupling ReactionAlkene MetathesisDrug DiversificationArylacetic AcidOrganic ChemistryOrganometallic CatalysisCatalysisChemistryNitrile-based Directing GroupBiomolecular Engineering
A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.
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