Neurotoxic and Nephrotoxic Effects of Colistin in Patients with Renal Disease

Abstract

COLISTIN is an antibiotic which, although similar to polymyxin B in chemical structure and antimicrobial spectrum, produces significantly fewer toxic reactions in man. The present report describes potentially serious reactions to colistin§ in 3 adults with impaired kidney function and in a child who was given ten times the recommended dosage.Case ReportsCase 1. S.S., a 13-year-old white boy, was admitted to the hospital for treatment of a refractory chronic otitis media associated with pseudomonas. His weight was 42.6 kg. (94 pounds). Although colistin was prescribed in a dosage of 25 mg. every 6 hours he was inadvertently given . . .