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The synthesis and antilipidperoxidation activity of 4,4-diarylbutylamines and 4,4-diarylbutanamides.
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1990
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Medicinal ChemistryDerivative (Chemistry)Bioorganic ChemistryOxysterolBiochemistryNatural SciencesSignificant Alp ActivityChemical DerivativeOrganic ChemistryAntilipidperoxidation Activity4,4-Diarylbutanamide DerivativesHeterocycle ChemistryPharmacologyPharmaceutical ChemistrySynthetic ChemistryAcute Toxicity
A series of 4,4-diarylbutylamine and 4,4-diarylbutanamide derivatives has been synthesized and evaluated for their antilipidperoxidation (ALP) activity and acute toxicity (LD50). Some of them were found to have significant ALP activity.