Gastric Secretion in Dogs Treated with Histamine Antagonist, Thymoxyethyldiethylamine

Abstract

SummaryStudies on gastric secretion in dogs provided with Heidenhain pouches definitely indicated that 929F, given subcutaneously, did not induce gastric secretion. However, following an injection of histamine in animals thus treated, the gastric secretion was markedly increased in volume and acidity over that which was obtained during control periods when only the histamine stimulus was employed.These findings indicate that 929F, in the doses employed, neither destroys histamine nor antagonizes the action of histamine as a gastric secretory stimulant.