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Electron Microscopic Visualization of Transcription
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1970
Year
MicroscopyElectron Microscopic VisualizationMolecular BiologyMolecular GeneticsGene TranscriptionCellular PhysiologyProtein SynthesisElectron MicroscopyGene StructureBiological Network VisualizationAmphibian OocyteProkaryotic SystemBacterium Escherichia ColiCell DivisionDna ReplicationGene ExpressionCell BiologyProtein BiosynthesisBiologyChromatinNatural SciencesCellular StructureMedicineTranslation Migrate
With the possible exception of DNA-containing cytoplasmic organelles, transcription and translation are compartmentalized in eucaryotic cells. That is, RNA polymerases transcribe nuclear DNA, and the various RNAs involved in translation migrate to the cytoplasm where protein synthesis occurs. On the other hand, in procaryotic cells, transcription and translation occur in the same region of the cell, at the same time, and in a coordinated manner. The transcription process has now been observed in both a eucaryotic cell, the amphibian oocyte (Miller and Beatty, 1969a, c), and in a procaryotic cell, the bacterium Escherichia coli (Miller et al., 1970).