ANTIBIOTIC PRODUCTION BY NEW FORM-GENERA OF THE ACTINOMYCETALES. I

Abstract

A new antibiotic producing actinomyces belonging to the genus Planomonospora is described. Detailed description of its morphological and some of its biochemical characters are given. The antibiotic for which the name sporangiomycin is proposed can be produced successfully under submerged conditions. Sporangiomycin was found to belong to the depsipeptide or peptolide group of antibiotics, and is related to thiostrepton. The antibiotic is highly active in vitro against gram-positive bacteria, and protects mice from streptococcal and diplococcal infections.