A Repression-derepression Mechanism Regulating the Transcription of Human Immunodeficiency Virus Type 1 In Primary T Cells

Abstract

This regulation exerted by cellular transcription factors can account for several important features of HIV-1 expression in primary CD4+ cells. Tight repression in resting naive T helper cells may be a main cause of viral latency and transcriptional activation accounts for massive viral production in activated T lymphocytes.