Familial Nonhemolytic Jaundice with Normal Liver Histology and Conjugated Bilirubin

Abstract

RECENTLY there has been considerable interest concerning two syndromes of familial nonhemolytic jaundice. The first syndrome has had various designations: Gilbert's disease1; familial nonhemolytic jaundice2; constitutional hyperbilirubinemia3; and constitutional hepatic dysfunction.4 This disease is characterized clinically by the presence of jaundice, which is either fluctuating or persistent. The patient remains in good health. The serum bilirubin levels are usually less than 6 mg. per 100 ml. and react with the van den Bergh reagent to give predominantly the indirect reaction. A variant of this syndrome was described by Crigler and Najjar5 as occurring in infants in whom . . .