Copper-Catalyzed Oxidative Cyclization of 1,5-Enynes with Concomitant C–C Bond Cleavage: An Unexpected Access to 3-Formyl-1-indenone Derivatives

Abstract

A Cu(0)/Selectfluor system-mediated oxidative cyclization of 1,5-enynes with concomitant C-C bond cleavage to access 3-formyl-1-indenone derivatives is described. Preliminary mechanistic investigations disclosed that the C-C bond cleavage involved a novel water-participated oxygen-insertion β-carbon elimination through double oxycuprations.