Early Histological Changes Following Obstruction of Pancreatic Ducts in Dogs: Correlation with Serum Amylase

Abstract

Both pancreatic ducts were ligated in 3 dogs. Over a period of 24 hours a gradual rise of serum amylase and a moderate edema with a slight leukocytic infiltration of the interlobular connective tissue of the pancreas occurred. The pancreatic duct systems of five dogs were subjected to a pressure of 30 cm water. Serum amylase rose twice as fast as in the dogs with simple ligation. Histologically, the principal changes in the pancreas were a more intense leukocytic infiltration, including acinar areas, and degeneration of some acinar cells.