Spasmolytic substances from Cimicifuga dahurica Maxim.

Abstract

The search for spasmolytic principals of Cimicifuga dahurica MAXIM. (Ranunculaceae) with the guidance of the intestinal action resulted in the isolation of two active substances, visamminol and visnagin, in addition to isoferulic acid and norvisnagin. Norvisnagin was first isolated from natural source. Pharmacological estimations using guinea pig jejunum revealed that the spasmolytic actions of visamminol and visnagin were one-third and one-tenth that of papaverine hydrochloride, respectively. Norvisnagin showed inactivity.