One-Pot Synthesis of 2,5-Diformylfuran from Carbohydrate Derivatives by Sulfonated Resin and Hydrotalcite-Supported Ruthenium Catalysts

Abstract

2,5-Diformylfuran (DFF) was selectively synthesized from 5-hydroxymethylfurfural using a hydrotalcite-supported ruthenium catalyst (Ru/HT) by oxidation with molecular oxygen under mild reaction conditions. A combination of hydrotalcite, Amberlyst-15, and Ru/HT catalysts successfully afforded direct synthesis of DFF from hexoses such as fructose and glucose via isomerization, dehydration, and successive selective oxidation in one pot. Stepwise addition of catalyst improved DFF yield up to 49% from fructose and 25% from glucose, respectively.