Orthopedic Trauma Directions · 2010 · 39 citations · 0 references
MedicineOrthopaedic SurgeryOrthopedic SurgeryBone GraftingOrthopedicsRegenerative MedicineBone HealingBone RegenerationBone Tissue EngineeringFracture FixationFracture RepairSynthetic Bone SubstitutesBone RepairFracture Fixation Infection PreventionFracture HealingIntramedullary Nail InfectionOpen Fracture ReconstructionPostoperative Wound HealingTibial Fracture RepairTibial Plateau Fracture
Author summary Four hundred and fifty patients with an open tibial fracture were randomized to receive either intramedullary nail fixation and routine soft-tissue management only, or with the addition of an implant containing either 0.75 mg / mL or 1.50 mg / mL of recombinant human bone morphogenetic protein-2 (rhBMP-2). In this study, the use of 1.50 mg / mL of rhBMP significantly reduced the number and invasiveness of secondary procedures, accelerated fracture and wound healing, and reduced the rates of infection, hardware failure, and overall pain.