Concepedia

A pilot study of dexmedetomidine sedation and caudal anesthesia for inguinal hernia repair in infants

Choon Looi Bong, Angela S. H. Yeo, Teddy Fabila, Josephine Tan

Pediatric Anesthesia · 2016 · 29 citations · 24 references

DOI

Abstract

Dexmedetomidine sedation with caudal anesthesia is a feasible alternative to spinal or general anesthesia in selected infants undergoing uncomplicated hernia surgery. It avoids the need for endotracheal intubation and may be potentially beneficial in avoiding the unknown effects of general anesthesia on neurodevelopment.

References

24

Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits

Vesna Jevtović‐Todorović, Richard E. Hartman, Yukitoshi Izumi et al. · Journal of Neuroscience · 2003 · 2K citations · Full text

Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

Robert T. Wilder, Randall P. Flick, Juraj Šprung et al. · Anesthesiology · 2009 · 1.4K citations · Full text

Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial

Andrew Davidson, Nicola Disma, Jurgen C. de Graaff et al. · The Lancet · 2015 · 1.1K citations · Full text

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Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey

William Slikker, X. Zou, Charlotte E. Hotchkiss et al. · Toxicological Sciences · 2007 · 609 citations

Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia

Caleb Ing, Charles DiMaggio, Andrew Whitehouse et al. · PEDIATRICS · 2012 · 606 citations