The Studies on Quinolizinium Salts. II. Ring Opening Reactions of Quinolizinium Bromide by Grignard Reagents

Abstract

Quinolizinium bromide (V) reacts with warious Grignard reagents giving two geometric isomers of ring opened products respectively. The reaction intermediate would be a 4-substituted-4H-quinolizine derivative (IV) which rearranges to the more stable pyridine derivative (i.e., VIII).