Action of Chloromycetin on Salmonella

Abstract

Chloromycetin inhibits the growth of Salmonella organisms in vitro remarkably, but is not able even in large amounts to control Salmonella infections in mice. Neither the oral nor the subcutaneous form of treatment prevented the fatal outcome of the disease in most animals, although it prolonged the survival time. Its action in the animals was bacteriostatic and not bactericidal. Due to its absorption conditions, Chloromycetin exerts no influence on the intestinal flora, when given orally.