Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the β₃-Adrenergic–Receptor Gene

Abstract

Pima subjects homozygous for the Trp64Arg beta 3-adrenergic-receptor mutation have an earlier onset of NIDDM and tend to have a lower resting metabolic rate. This mutation may accelerate the onset of NIDDM by altering the balance of energy metabolism in visceral adipose tissue.