Absorption of salicylic acid through the oral mucous membrane of hamster cheek pouch.

Abstract

Ointments containing salicylic acid were applied to the cheek pouch of the hamster, and the influence of the type of base on drug absorption at the mucous membrane of the oral cavity was examined. Clear differences in absorption were found : emulsion base water-soluble base oleaginous base. Furthermore, the absorption of salicylic acid into the blood was closely related to drug retention in the tissue of the mucous membrane. The results of in vitro membrane permeation experiments corresponded very well with the results of the absorption experiments in vivo.