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Renal and Pulmonary Alterations Induced in Rats by a Single Injection of Monocrotaline.
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1967
Year
Acute Lung InjuryHypertensionVascular DiseaseRenal InflammationRight Ventricular HypertrophyPulmonary HypertensionExperimental PharmacologyPulmonary Alterations InducedMolecular PharmacologyGlomerulonephritisThrombosisPulmonary Arterial InjuryPulmonary PharmacologyToxicologyPublic HealthRenal PharmacologyCardiologyPulmonary CirculationVascular BiologySingle InjectionRenal PathophysiologyPharmacologyPulmonary Vascular DiseasePulmonary Arterial HypertensionCardiovascular DiseasePhysiologyMedicineNephrologyKidney ResearchAnesthesiology
SummaryA single subcutaneous injection of monocrotaline produced various grades of pulmonary arterial injury including necrotizing arteritis in rats. The arterial lesions were presumed to be sequelae of long standing pulmonary hypertension as manifested by right ventricular hypertrophy. It was noted that monocrotaline could also produce a renal hemosiderosis, as well as glomerular necrosis in association with hyaline thrombosis in the glomerular capillaries and afferent arterioles.