Mechanism of Hypoglycorrhachia in Experimental Pneumococcal Meningitis.

Abstract

Pneumococcal meningitis was produced in normal and irradiated dogs. The latter became leukopenic and the pleocytosis occurring in the CSF in response to the infection was suppressed. The number of bacteria in the CSF was the same in both groups, but CSF sugars remained consistently normal in the irradiated animals while hypoglycorrhachia occurred in 50% of controls. These findings suggest that both cells and bacteria are necessary to lower the CSF sugar in bacterial meningitis.