Experimental Biology and Medicine · 1969 · 20 citations · 0 references
Life SciencesImmunologyMolecular BiologyImmunopathologyMolecular VirologyVirologyAntiviral ImmunityInterferon ResponsesViral InfectionsAntiviral Interferon ResponsesAntiviral Mechanisms Of ActionCytomegalovirus DiseaseDouble-stranded Rna VirusesInhibition Of Interferon ResponsesInterferon ProductionInterferon Response To Viral InfectionPlaque Reduction
Poly Ir-Cr, a synthetic double-stranded RNA which is a potent interferon inducer, produces marked plaque reduction of human cytomegalovirus in human fibroblasts. The material is active in human fibroblasts which are sensitive to the antiviral action of interferon (AH-1 cells) while it is not active in human fibroblasts which are relatively resistant to interferon (WI-38).