Design and Characterization of an Ocular Topical Liposomal Preparation to Replenish the Lipids of the Tear Film

Abstract

The unpreserved liposomal formulation has suitable properties to be administered by a topical ophthalmic route. The liposome-based artificial tear had good in vitro and in vivo tolerance responses. This formulation, composed of a combination of liposomes and bioadhesive polymers, may be used successfully as a tear film substitute in DE therapy.