Fibrotic Disorders Associated with Methysergide Therapy for Headache

Abstract

THE development of retroperitoneal fibrosis in 27 patients using methysergide for the prevention of headache is the occasion for this report. Irving Beck, of Providence, Rhode Island, was the first to suggest a possible connection between methysergide and retroperitoneal fibrosis in July, 1961, when this condition developed in 1 of his patients, supplied with this drug by one of us. When a second patient taking methysergide for headache was similarly afflicted in November, 1962, the 2 cases were reported.1 Since then, as of October, 1965, our attention has been directed to a total of 27 patients in whom, while they . . .