Hyaluronidase Activity of Normal and Neoplastic Interstitial Fluid

Abstract

The hyaluronidase activity of the interstitial fluid of Walker carcinoma transplanted into Sprague-Dawley rats was sharply increased when compared with the activity of normal subcutaneous interstitial fluid. On the contrary, the hyaluronidase activity in blood serum of tumor-bearing rats was depressed as compared with the activity of normal serum. The implications of these findings are briefly discussed.