Experimental Biology and Medicine · 1970 · 32 citations · 0 references
MedicineNeurosciencePharmacologyNeurochemistryNeuropharmacologyPsychopharmacologyAlcohol PharmacodynamicsAlcohol PharmacologyMonoamine NeurochemistryNeurochemical PharmacologySerotonergic PharmacologySubstance IntoxicationAcute Ethanol IntoxicationBrain Ethanol ConcentrationMonoamine Oxidase InhibitionMonoamine Oxidase InhibitorsMonoamine Oxidase InvolvementMonoamine TurnoverNeurobehavioral Effects Of IntoxicationSerotonergic System Effects
In rats which had received an intoxicating dose of ethanol, the concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the brain were not different from concentrations in brains of normal rats. The turnover of cerebral 5-HT, determined from rates of increase in concentration of 5-HT or of decrease in concentration of 5-HIAA after the administration of a monoamine oxidase inhibiter, was modestly decreased during ethanol intoxication.