Focal Hepatitis, Fever and Skin Rash Following Therapy with Sulfamethoxypyridazine, a Long-Acting Sulfonamide

Abstract

SINCE their introduction as clinical chemotherapeutic agents, the sulfonamide derivatives have been implicated repeatedly as sensitizing agents capable of producing "allergic" types of drug reactions. Although the occurrence of such untoward reactions has been greatly reduced with the newer compounds, fever, skin rashes, hematopoietic disorders and renal and hepatic dysfunction continue to complicate sulfonamide therapy in a small fraction of cases. For this reason, awareness of potential sensitization by these agents and prompt recognition of its clinical manifestations are of continuing importance.To date, only transient skin rash and drug fever1 have been listed as hypersensitivity complications of treatment with . . .