Studies on Antitubercular Compounds. X. Condensation Products of Aldehydes and Acid Hydrazides of Pyridine Group

Abstract

Nine condensation products of isomeric three aldehydes and three acid hydrazides of pyridine group were prepared and their tuberculostatic activity against virulent human tubercle bacillus, strain H37Rv, was examined on Kirchner's medium containing 10% of bovine serum. The most active compounds were the condensation products of isonicotinic acid hydrazide with aldehydes and stronger than isonicotinic acid hydrazide in vitro.