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In(III)/PhCO<sub>2</sub>H Binary Acid Catalyzed Tandem [2 + 2] Cycloaddition and Nazarov Reaction between Alkynes and Acetals
46
Citations
64
References
2013
Year
Cross-coupling ReactionEngineeringBiochemistryBenzoic AcidNatural SciencesOrganic ChemistryNazarov ReactionCatalysisOrganometallic CatalysisChemistryHeterocycle ChemistryFacile TandemAsymmetric CatalysisEnantioselective Synthesis
A facile tandem [2 + 2] cycloaddition and Nazarov reaction has been developed. The combination of In(OTf)3 and benzoic acid was found to synergistically promote the coupling of alkynes and acetals to form 2,3-disubstituted indanones in excellent yield and diastereoselectivity.
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