Alleviation of Anaphylactic Shock in Guinea Pigs With Synthetic Benzhydryl Alkamine Ethers

Abstract

The hydrochlorides of β-dimethylaminoethyl- and β-morpholinoethyl benzhydryl ether proved to be markedly effective in alleviating anaphylactic shock in guinea pigs. The potency of the former compound may equal or exceed that of 1571F, the most effective Fourneau histamine antagonist. These antispasmodic benzhydryl ethers should prove useful in studies dealing with the role of histamine in various physiological mechanisms and pathological conditions.