Comparison of Intravenous and Intragastric Aspirin in Production of Antral Gastric Ulcers in Cats

Abstract

In cats receiving continuous intravenous infusion of histamine dihydrochloride (160 μg kg-1 hr-1; 40 mg kg-1 of aspirin was given as a bolus injection either intravenously or intragastrically. When the animals were killed either 1 or 4 hr later, all cats in both groups had ulcers of the antral part of the stomach extending through the mucosa. The mean area occupied by the ulcers was not significantly different in the two groups. Plasma and mucosal salicylate concentrations at the end of the study were not significantly different in the two groups. We conclude that, in cats receiving an intravenous infusion of histamine, intravenous and intragastric aspirin are equally effective in producing antral gastric ulcers.