Publication | Closed Access
The Application of Dialkylphosphite as the Amino Protection Reagent in Organic Synthesis
12
Citations
4
References
1983
Year
Derivative (Chemistry)DerivativesBioorganic ChemistryBiochemistryPhosphoryl DerivativesNatural SciencesEngineeringAcid HydrolysisOrganic ChemistryPeptide SynthesisChemistryP-n BondsAmino Protection ReagentEnzymatic ModificationChemical DerivativeSynthetic ChemistryBiomolecular Engineering
Abstract The acid hydrolysis of N-phenyl-N-dialkyl-phosphoramidates was studied by HPLC, the N-phenyl-N-diisopropylphosphoramidate has half life 53 min in 6N HCl at 50°C. The P-N bonds of these phosphoryl derivatives also show a relative stability in organic and Lewis acids.
| Year | Citations | |
|---|---|---|
Page 1
Page 1