Reactivation of a Bovine Herpesvirus After Corticosteroid Treatment

Abstract

SummaryConsistent recrudescence of IBR virus from latently infected cattle following a series of inoculations of a synthetic corticosteroid has been demonstrated. In addition IBR virus was frequently recovered from the tissues of the upper respiratory tract, and irregularly in a number of other organs by organ culture techniques. While IBR virus was recovered from all treated animals it was never recovered from nasal and conjunctival secretions of control animals or from treated animals until after 3 days of steroid inoculations and was recovered from tissues of only 1/9 untreated animals.We are grateful to Miss Susan Rodman and Mrs. Pamela Natowsky for their excellent technical assistance.