The Anatomy of the Posterior Communicating Artery as a Risk Factor for Ischemic Cerebral Infarction

TLDR

After internal carotid artery occlusion, collateral flow mainly comes from the circle of Willis, but the size and patency of these arteries vary. The study aimed to determine whether anatomical patterns of collateral pathways in patients with internal carotid artery occlusion could protect against watershed infarction. Using conventional MRI and 3‑D phase‑contrast MRA, the authors evaluated 29 patients (32 hemispheres) and assessed four collateral routes—the proximal ACA, posterior communicating artery, ophthalmic artery, and leptomeningeal collaterals from the PCA. Patients with a posterior communicating artery ≥1 mm had no watershed infarcts, whereas those with a <1 mm or absent PComA had a higher incidence of infarction, indicating that a small or absent ipsilateral posterior communicating artery is a risk factor for ischemic cerebral infarction in internal carotid artery occlusion.

Abstract

After the occlusion of an internal carotid artery the principal source of collateral flow is through the arteries of the circle of Willis, but the size and patency of these arteries are quite variable. Study of the anatomy of the collateral pathways in patients with internal-carotid-artery occlusion with or without infarction in the watershed area of the deep white matter may identify patterns that afford protection from ischemic infarction.Using conventional magnetic resonance imaging and three-dimensional phase-contrast magnetic resonance angiography, we evaluated 29 consecutive patients (32 hemispheres at risk) with angiographically proved occlusion of the internal carotid artery. Four collateral pathways to the occluded vessel were evaluated: the proximal segment of the anterior cerebral artery, the posterior communicating artery, the ophthalmic artery, and leptomeningeal collateral vessels from the posterior cerebral artery.Only features of the ipsilateral posterior communicating artery were related to the risk of watershed infarction. The presence of posterior communicating arteries measuring at least 1 mm in diameter was associated with the absence of watershed infarction (13 hemispheres, no infarcts; P < 0.001). Conversely, there were 4 watershed infarcts in the 6 hemispheres with posterior communicating arteries measuring less than 1 mm in diameter and 10 infarcts in the 13 hemispheres with no detectable flow in the ipsilateral posterior communicating artery.A small (< 1 mm in diameter) or absent ipsilateral posterior communicating artery is a risk factor for ischemic cerebral infarction in patients with internal-carotid-artery occlusion.