MedChemComm · 2016 · 57 citations · 33 references
PharmacyMedicinal ChemistryPharmacologyDementiaDrug DesignDrug DiscoveryDementia PharmacotherapyLead Compound DesignLigand-based DesignMulti-target Drug DesignNeurodegenerative Disease PharmacologyNeurodegenerative Disease PharmacotherapyDementia Drug DevelopmentFragment-based Multi-target DesignLigand-based Multi-target DesignMedicinal Chemistry ApplicationsMolecular HybridsMulti-target Ligand DesignMultitarget Drug DesignPharmacological Treatment Of Dementia
A novel family of donepezil–ferulic acid hybrids were designed, synthesized and biologically evaluated as multi-target-directed ligands against Alzheimer's disease by fusing a fragment of donepezil and ferulic acid.
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A new and rapid colorimetric determination of acetylcholinesterase activity
George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations