Publication | Open Access
Pushing phase and amplitude sensitivity limits in interferometric microscopy
84
Citations
13
References
2016
Year
EngineeringInstrument DesignMicroscopyInterferometryShot Noise ContributionMicroscopy MethodComputational ImagingLight MicroscopyBiophysicsPhotonicsPhysicsPhoton Shot NoiseComputational Optical ImagingAmplitude Sensitivity LimitsApplied PhysicsBiomedical ImagingElectron MicroscopeQuantitative Phase ImagingMedicine
Sensitivity of the amplitude and phase measurements in interferometric microscopy is influenced by factors such as instrument design and environmental interferences. Through development of a theoretical framework followed by experimental validation, we show photon shot noise is often the limiting factor in interferometric microscopy measurements. Thereafter, we demonstrate how a state-of-the-art camera with million-level electrons full well capacity can significantly reduce shot noise contribution resulting in a stability of optical path length down to a few picometers even in a near-common-path interferometer.
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