Expression of Integrin αVβ3 in Pancreatic Carcinoma: Relation to MMP-2 Activation and Lymph Node Metastasis

Abstract

Expression analysis in pancreatic cancer tissue demonstrated involvement of alphaVbeta3 integrin in lymph node metastasis rather than peripancreatic invasion. MMP-2 activation is linked, at least in part, to the expression of integrin alphaVbeta3 of pancreatic cancer cells.