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A Comparison of Spontaneous and Ultraviolet-Induced Allelic Recombinaton with Reference to the Recombination of Outside Markers
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1958
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GeneticsReproductive GeneticsMolecular BiologyMolecular GeneticsUltraviolet-induced Allelic RecombinatonGene Conversion HypothesisSomatic GeneticsIrregular SegregationsConversion HypothesisOutside MarkersGene TransferQuantitative GeneticsHybridizationMeiosisGenetic VariationChromosomal RearrangementGene ExpressionPopulation GeneticsBiologyLinkage DisequilibriumAllelic VariantNatural SciencesEvolutionary BiologyGenetic MechanismRecombination DynamicMedicineMendelian InheritanceMutagenesis
In 1930, Winkler proposed the gene conversion hypothesis as an alternative to crossing over to account for recombination between linked markers. According to his hypothesis, one of the two alleles of a heterozygote is able to “convert” the other to its own likeness. Since 1949, Lindegren and his co-workers (Lindegren, 1949, 1953, 1955) have adopted the conversion hypothesis to explain irregular segregations in yeast, namely, segregations of 4:0, 3:1, 1:3, and 0:4 for the dominant:recessive ratio in asci from cells presumed to be diploid and heterozygous.